心血管疾病（CVD）是全球死亡的第一大原因。尽管有越来越多的证据表明心房颤动（AF）与各种CVD有着密切的关联，但这种心律不齐通常是使用心电图（ECG）诊断的，这是一种无风险，无侵入性和具有成本效益的工具。在任何威胁生命的疾病/疾病发展之前，不断和远程监视受试者的心电图信息迅速诊断和及时对AF进行预处理的潜力。最终，可以降低CVD相关的死亡率。在此手稿中，展示了体现可穿戴心电图设备，移动应用程序和后端服务器的个性化医疗系统的设计和实施。该系统不断监视用户的心电图信息，以提供个性化的健康警告/反馈。用户能够通过该系统与他们的配对健康顾问进行远程诊断，干预措施等。已经评估了实施的可穿戴ECG设备，并显示出极好的一致性（CVRMS = 5.5％），可接受的一致性（CVRMS = CVRMS = CVRMS = 12.1％），可忽略不计的RR间隙错误（<1.4％）。为了提高可穿戴设备的电池寿命，提出了使用ECG信号的准周期特征来实现压缩的有损压缩模式。与公认的架构相比，它在压缩效率和失真方面优于其他模式，并在MIT-BIH数据库中以ECG信号的某个PRD或RMSE达到了至少2倍的Cr。为了在拟议系统中实现自动化AF诊断/筛查，开发了基于重新系统的AF检测器。对于2017年Physionet CINC挑战的ECG记录，该AF探测器获得了平均测试F1 = 85.10％和最佳测试F1 = 87.31％，表现优于最先进。

Weakly-supervised object localization aims to indicate the category as well as the scope of an object in an image given only the image-level labels. Most of the existing works are based on Class Activation Mapping (CAM) and endeavor to enlarge the discriminative area inside the activation map to perceive the whole object, yet ignore the co-occurrence confounder of the object and context (e.g., fish and water), which makes the model inspection hard to distinguish object boundaries. Besides, the use of CAM also brings a dilemma problem that the classification and localization always suffer from a performance gap and can not reach their highest accuracy simultaneously. In this paper, we propose a casual knowledge distillation method, dubbed KD-CI-CAM, to address these two under-explored issues in one go. More specifically, we tackle the co-occurrence context confounder problem via causal intervention (CI), which explores the causalities among image features, contexts, and categories to eliminate the biased object-context entanglement in the class activation maps. Based on the de-biased object feature, we additionally propose a multi-teacher causal distillation framework to balance the absorption of classification knowledge and localization knowledge during model training. Extensive experiments on several benchmarks demonstrate the effectiveness of KD-CI-CAM in learning clear object boundaries from confounding contexts and addressing the dilemma problem between classification and localization performance.

Knowledge graph embedding (KGE), which maps entities and relations in a knowledge graph into continuous vector spaces, has achieved great success in predicting missing links in knowledge graphs. However, knowledge graphs often contain incomplete triples that are difficult to inductively infer by KGEs. To address this challenge, we resort to analogical inference and propose a novel and general self-supervised framework AnKGE to enhance KGE models with analogical inference capability. We propose an analogical object retriever that retrieves appropriate analogical objects from entity-level, relation-level, and triple-level. And in AnKGE, we train an analogy function for each level of analogical inference with the original element embedding from a well-trained KGE model as input, which outputs the analogical object embedding. In order to combine inductive inference capability from the original KGE model and analogical inference capability enhanced by AnKGE, we interpolate the analogy score with the base model score and introduce the adaptive weights in the score function for prediction. Through extensive experiments on FB15k-237 and WN18RR datasets, we show that AnKGE achieves competitive results on link prediction task and well performs analogical inference.

When robots learn reward functions using high capacity models that take raw state directly as input, they need to both learn a representation for what matters in the task -- the task ``features" -- as well as how to combine these features into a single objective. If they try to do both at once from input designed to teach the full reward function, it is easy to end up with a representation that contains spurious correlations in the data, which fails to generalize to new settings. Instead, our ultimate goal is to enable robots to identify and isolate the causal features that people actually care about and use when they represent states and behavior. Our idea is that we can tune into this representation by asking users what behaviors they consider similar: behaviors will be similar if the features that matter are similar, even if low-level behavior is different; conversely, behaviors will be different if even one of the features that matter differs. This, in turn, is what enables the robot to disambiguate between what needs to go into the representation versus what is spurious, as well as what aspects of behavior can be compressed together versus not. The notion of learning representations based on similarity has a nice parallel in contrastive learning, a self-supervised representation learning technique that maps visually similar data points to similar embeddings, where similarity is defined by a designer through data augmentation heuristics. By contrast, in order to learn the representations that people use, so we can learn their preferences and objectives, we use their definition of similarity. In simulation as well as in a user study, we show that learning through such similarity queries leads to representations that, while far from perfect, are indeed more generalizable than self-supervised and task-input alternatives.

Vision-language models (VLMs) that are pre-trained on large-scale image-text pairs have demonstrated impressive transferability on a wide range of visual tasks. Transferring knowledge from such powerful pre-trained VLMs is emerging as a promising direction for building effective video recognition models. However, the current exploration is still limited. In our opinion, the greatest charm of pre-trained vision-language models is to build a bridge between visual and textual domains. In this paper, we present a novel framework called BIKE which utilizes the cross-modal bridge to explore bidirectional knowledge: i) We propose a Video Attribute Association mechanism which leverages the Video-to-Text knowledge to generate textual auxiliary attributes to complement video recognition. ii) We also present a Temporal Concept Spotting mechanism which uses the Text-to-Video expertise to capture temporal saliency in a parameter-free manner to yield enhanced video representation. The extensive studies on popular video datasets (ie, Kinetics-400 & 600, UCF-101, HMDB-51 and ActivityNet) show that our method achieves state-of-the-art performance in most recognition scenarios, eg, general, zero-shot, and few-shot video recognition. To the best of our knowledge, our best model achieves a state-of-the-art accuracy of 88.4% on challenging Kinetics-400 with the released CLIP pre-trained model.

There is a growing interest in developing unlearnable examples (UEs) against visual privacy leaks on the Internet. UEs are training samples added with invisible but unlearnable noise, which have been found can prevent unauthorized training of machine learning models. UEs typically are generated via a bilevel optimization framework with a surrogate model to remove (minimize) errors from the original samples, and then applied to protect the data against unknown target models. However, existing UE generation methods all rely on an ideal assumption called label-consistency, where the hackers and protectors are assumed to hold the same label for a given sample. In this work, we propose and promote a more practical label-agnostic setting, where the hackers may exploit the protected data quite differently from the protectors. E.g., a m-class unlearnable dataset held by the protector may be exploited by the hacker as a n-class dataset. Existing UE generation methods are rendered ineffective in this challenging setting. To tackle this challenge, we present a novel technique called Unlearnable Clusters (UCs) to generate label-agnostic unlearnable examples with cluster-wise perturbations. Furthermore, we propose to leverage VisionandLanguage Pre-trained Models (VLPMs) like CLIP as the surrogate model to improve the transferability of the crafted UCs to diverse domains. We empirically verify the effectiveness of our proposed approach under a variety of settings with different datasets, target models, and even commercial platforms Microsoft Azure and Baidu PaddlePaddle.

We consider the problem of estimating a multivariate function $f_0$ of bounded variation (BV), from noisy observations $y_i = f_0(x_i) + z_i$ made at random design points $x_i \in \mathbb{R}^d$, $i=1,\ldots,n$. We study an estimator that forms the Voronoi diagram of the design points, and then solves an optimization problem that regularizes according to a certain discrete notion of total variation (TV): the sum of weighted absolute differences of parameters $\theta_i,\theta_j$ (which estimate the function values $f_0(x_i),f_0(x_j)$) at all neighboring cells $i,j$ in the Voronoi diagram. This is seen to be equivalent to a variational optimization problem that regularizes according to the usual continuum (measure-theoretic) notion of TV, once we restrict the domain to functions that are piecewise constant over the Voronoi diagram. The regression estimator under consideration hence performs (shrunken) local averaging over adaptively formed unions of Voronoi cells, and we refer to it as the Voronoigram, following the ideas in Koenker (2005), and drawing inspiration from Tukey's regressogram (Tukey, 1961). Our contributions in this paper span both the conceptual and theoretical frontiers: we discuss some of the unique properties of the Voronoigram in comparison to TV-regularized estimators that use other graph-based discretizations; we derive the asymptotic limit of the Voronoi TV functional; and we prove that the Voronoigram is minimax rate optimal (up to log factors) for estimating BV functions that are essentially bounded.

We study the task of learning state representations from potentially high-dimensional observations, with the goal of controlling an unknown partially observable system. We pursue a direct latent model learning approach, where a dynamic model in some latent state space is learned by predicting quantities directly related to planning (e.g., costs) without reconstructing the observations. In particular, we focus on an intuitive cost-driven state representation learning method for solving Linear Quadratic Gaussian (LQG) control, one of the most fundamental partially observable control problems. As our main results, we establish finite-sample guarantees of finding a near-optimal state representation function and a near-optimal controller using the directly learned latent model. To the best of our knowledge, despite various empirical successes, prior to this work it was unclear if such a cost-driven latent model learner enjoys finite-sample guarantees. Our work underscores the value of predicting multi-step costs, an idea that is key to our theory, and notably also an idea that is known to be empirically valuable for learning state representations.

Deep learning has been widely used for protein engineering. However, it is limited by the lack of sufficient experimental data to train an accurate model for predicting the functional fitness of high-order mutants. Here, we develop SESNet, a supervised deep-learning model to predict the fitness for protein mutants by leveraging both sequence and structure information, and exploiting attention mechanism. Our model integrates local evolutionary context from homologous sequences, the global evolutionary context encoding rich semantic from the universal protein sequence space and the structure information accounting for the microenvironment around each residue in a protein. We show that SESNet outperforms state-of-the-art models for predicting the sequence-function relationship on 26 deep mutational scanning datasets. More importantly, we propose a data augmentation strategy by leveraging the data from unsupervised models to pre-train our model. After that, our model can achieve strikingly high accuracy in prediction of the fitness of protein mutants, especially for the higher order variants (> 4 mutation sites), when finetuned by using only a small number of experimental mutation data (<50). The strategy proposed is of great practical value as the required experimental effort, i.e., producing a few tens of experimental mutation data on a given protein, is generally affordable by an ordinary biochemical group and can be applied on almost any protein.

Future work sentences (FWS) are the particular sentences in academic papers that contain the author's description of their proposed follow-up research direction. This paper presents methods to automatically extract FWS from academic papers and classify them according to the different future directions embodied in the paper's content. FWS recognition methods will enable subsequent researchers to locate future work sentences more accurately and quickly and reduce the time and cost of acquiring the corpus. The current work on automatic identification of future work sentences is relatively small, and the existing research cannot accurately identify FWS from academic papers, and thus cannot conduct data mining on a large scale. Furthermore, there are many aspects to the content of future work, and the subdivision of the content is conducive to the analysis of specific development directions. In this paper, Nature Language Processing (NLP) is used as a case study, and FWS are extracted from academic papers and classified into different types. We manually build an annotated corpus with six different types of FWS. Then, automatic recognition and classification of FWS are implemented using machine learning models, and the performance of these models is compared based on the evaluation metrics. The results show that the Bernoulli Bayesian model has the best performance in the automatic recognition task, with the Macro F1 reaching 90.73%, and the SCIBERT model has the best performance in the automatic classification task, with the weighted average F1 reaching 72.63%. Finally, we extract keywords from FWS and gain a deep understanding of the key content described in FWS, and we also demonstrate that content determination in FWS will be reflected in the subsequent research work by measuring the similarity between future work sentences and the abstracts.